Penn State (-17) over Notre Dame
First and foremost - whoever plays Notre Dame, pick that team. All year, disregardless of the spread. After the Irish's trouncing of Penn State in 2006, expect Joe Pa and the boys from Happy Valley to run it up big time against Jabba the Hut and the boys.
Baylor (-6) over Rice
With a new head coach, new offensive, and just, well being Rice, the Owls should get trounced by Baylor. Guy Morriss has been turning the Bears around recently, and after the tough and tumble game against TCU last week, Baylor will be ready for some big time football.
Georgia (-4) over South Carolina
Lots of people like Spurrier's team going into Athens and covering against an unproven Georgia team. Until SC wins a big game against a big time SEC opponent, I expect the Bulldogs to handle the Gamecocks by a TD or more.
Miami (+10.5) at Oklahoma
OU is getting way too much respect after trouncing North Texas. Remember, North Texas is the team who hired a high school football coach to take over in Denton. While I think Todd Dodge will turn the Mean Green around in the future, this year's team is abysmal. OU will still have trouble against teams with a decent collection of athletes, including the Miami Hurricanes. The 10.5 points may be too much, even in Norman.
Va Tech (+12.5) at LSU
This game will be a defensive battle. I doubt the winner scores more than 17 points, and barring a shutout, odds are a 13 point victory is unlikely. Virginia Tech played an underrated East Carolina team amidst great emotion in Blacksburg. LSU pounded a terrible Mississippii State team. If you want to get crazy, go ahead and bet the parlay - Va Tech and the UNDER